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Updated: May 4, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Obesity and cardiovascular dysfunction: A role for resveratrol?
1Obesity Biology Unit, School of Clinical Science, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK.
Summary:
Obesity, characterized by excess adipose tissue is now becoming a worldwide epidemic. Various studies have suggested that obesity per se is an independent cardiovascular risk factor, as well as predisposing to type 2 diabetes, hypertension and dyslipidaemia. Furthermore, obesity induces insulin resistance, which is associated with development of cardiovascular diseases that include hypertension, and reduced endothelial function. A variety of pharmacological and physiological as well as surgical interventions have been used to counteract deleterious effects of obesity with some degree of success. A number of new medicinal agents are being considered as a candidate for managing obesity and its associated cardiovascular abnormalities. Resveratrol, a naturally occurring phenolic trihydroxystilbene substance, which is present in a variety of plants have been shown to reverse detrimental effects of diet-induced obesity. This review examines role of resveratrol as a future anti-obesity agent.:
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