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Updated: May 4, 2026

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Water-mediated inclusion of benzoates and tosylates inside the bambusuril macrocycle
Vaclav Havel1, Vladimir Sindelar, Marek Necas
1RECETOX, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. sindelar@chemi.muni.cz.
Abstract:
A supramolecular complex between benzoates and a bambusuril crystallizes out immediately after mixing in chloroform but only in the presence of residual water molecules. In this complex each of the two portals of the macrocycle is occupied by one benzoate. Carboxylate groups are connected through hydrogen bonding interactions with one molecule of water positioned between them in the center of the bambusuril cavity. Similar water assisted host-guest behavior was also observed when tosylates instead of benzoates were used.
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