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Feedback Inhibition

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!

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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.

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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.

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Related Experiment Video

Updated: May 4, 2026

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

The authors reply

Peter Pickkers¹, Niels Peek, Nicolet de Keizer

¹Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Medical Informatics, Academic Medical Centre, Amsterdam, The Netherlands Department of Medical Informatics, Academic Medical Centre, Amsterdam, The Netherlands, and National Intensive Care Evaluation, Amsterdam, The Netherlands.

Critical Care Medicine

|December 19, 2013

Summary

No abstract available in PubMed .

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