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The Extracellular Matrix

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Related Experiment Video

Updated: May 4, 2026

Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair

Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair

Published on: June 9, 2020

Initial experience with intraventricular repair using CorMatrix extracellular matrix.

Bobby Yanagawa¹, Vivek Rao, Terrence M Yau

¹From the Division of Cardiovascular Surgery, University Health Network, Department of Surgery, University of Toronto, Toronto, ON Canada.

Innovations (Philadelphia, Pa.)

|December 19, 2013

Summary

This summary is machine-generated.

CorMatrix extracellular matrix (ECM) shows promise as a safe alternative for repairing mechanical complications after myocardial infarction (MI). This novel material demonstrated integrity in ventricular patch repairs during short-term follow-up.

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Last Updated: May 4, 2026

Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair

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Published on: June 9, 2020

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Published on: December 4, 2017

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Published on: December 20, 2010

Area of Science:

Biomaterials Science
Cardiovascular Surgery
Regenerative Medicine

Background:

Traditional pericardial patches for intraventricular repair face limitations due to calcification, thickening, and retraction.
Mechanical complications following myocardial infarction (MI) necessitate effective repair strategies.

Purpose of the Study:

To evaluate the safety of CorMatrix extracellular matrix (ECM) for intraventricular repair of mechanical complications post-MI.
To assess the short-term efficacy and integrity of CorMatrix ECM in cardiac repair.

Main Methods:

CorMatrix ECM, derived from decellularized porcine small intestinal submucosa, was used for patch repair in 11 patients.
Patient cohort included ventricular aneurysm, ventricular septal defect (VSD), or both.
Clinical follow-up and transthoracic echocardiography were employed to monitor outcomes.

Main Results:

Eleven patients underwent repair using CorMatrix ECM for ventricular aneurysm and/or VSD.
No instances of CorMatrix ECM repair failure were observed.
Echocardiography confirmed the integrity of the CorMatrix ECM repair in all cases during follow-up periods up to 642 days.

Conclusions:

CorMatrix ECM presents a safe short-term alternative for ventricular patch repair in mechanical MI complications.
Further investigation into the efficacy and regenerative potential of CorMatrix ECM for cardiac repair is warranted.