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Effects of CYP2C19 genetic polymorphisms on atomoxetine pharmacokinetics

Chang-Ik Choi1, Jung-Woo Bae, Yun-Jeong Lee

  • 1From the *School of Pharmacy, Sungkyunkwan University, Suwon; †College of Pharmacy, Keimyung University, Daegu; and ‡College of Pharmacy, Dankook University, Cheonan, Republic of Korea.

Journal of Clinical Psychopharmacology
|December 19, 2013
PubMed
Summary

Genetic variations in CYP2C19 significantly impact atomoxetine pharmacokinetics. Poor metabolizers exhibit altered drug and metabolite levels, affecting treatment efficacy and safety in ADHD patients.

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