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Biological agents: investigation into leprosy and other infectious diseases before indication
João Roberto Antônio1, Rosa Maria Cordeiro Soubhia2, Vania Del Arco Paschoal3
1State Medical School of São José do Rio Preto, Base Hospital of São José do Rio Preto, Dermatology Department, São José do Rio PretoSP, Brazil.
Abstract:
Biological agents are widely used for various immune-mediated diseases, with remarkable effectiveness in the treatment of rheumatoid arthritis (RA), psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. However, attention needs to be drawn to the adverse effects of these therapies and the risk of reactivating underlying granulomatous infectious diseases such as tuberculosis, leprosy, syphilis, leishmaniasis, among others. The objective of this paper is to describe a case of leprosy in a patient with RA using anti-TNF alfa, demonstrating the need for systematic investigation of skin lesions suggestive of leprosy in patients who require rheumatoid arthritis therapeutic treatment, especially in endemic regions like Brazil.
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