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Primary cutaneous anaplastic large-cell lymphoma--case report.
Luciana Silveira Rabello de Oliveira1, Madeleyne Palhano Nobrega2, Maira Gomes Monteiro3
1Federal University of Campina Grande, Campina GrandePB, Brazil.
Anais Brasileiros De Dermatologia
|December 19, 2013
Summary
Primary cutaneous anaplastic large-cell lymphoma (pcALCL) is a CD30+ skin condition. This case highlights pcALCL
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Primary cutaneous anaplastic large-cell lymphoma (pcALCL) is a CD30+ lymphoproliferative disorder.
- It typically presents as ulcerated, recurrent skin nodules.
- Extracutaneous spread, particularly to lymph nodes, can occur.
Observation:
- A 57-year-old woman presented with multifocal pcALCL.
- Seven years post-diagnosis, she developed pulmonary involvement.
Findings:
- Histology revealed a diffuse, non-epidermotropic infiltrate of CD30+, CD4+ anaplastic large lymphoid cells.
- The patient responded well to weekly low-dose methotrexate treatment.
- Prognosis for pcALCL is generally favorable and independent of lymphatic invasion.
Implications:
- This case underscores the potential for late-stage extracutaneous dissemination in pcALCL.
- Low-dose methotrexate is an effective treatment option for pcALCL.
- Continued monitoring is crucial for patients with pcALCL due to recurrence and potential spread.
