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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Synthesis and biological evaluation of paleo-soraphens
Hai-Hua Lu1, Aruna Raja, Raimo Franke
1Institut für Organische Chemie und Biomolekulares, Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover (Germany); Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, Braunschweig (Germany).
Abstract:
Synthesis can provide molecules such as paleo-soraphens A and B that are genetically encoded but not obtained from the natural source. Although it is unclear whether this is part of an evolutionary process or the consequence of the chemical synthesis, the biological evaluation of these genetically encoded natural products can shed light on how natural products are structurally optimized with respect to their biological profile.
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