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Updated: May 4, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Primary leiomyosarcoma of saphenous vein presenting as deep venous thrombosis
Daniel I Fremed1, Peter L Faries2, Harry R Schanzer2
1Division of Vascular Surgery, The Mount Sinai Medical Center, New York, NY, USA daniel.fremed@mountsinai.org.
Abstract:
Only a small number of venous leiomyosarcomas have been previously reported. Of these tumors, those of saphenous origin comprise a minority of cases. A 59-year-old man presented with symptoms of deep vein thrombosis and was eventually diagnosed with primary leiomyosarcoma of great saphenous vein origin. The tumor was treated with primary resection and femoral vein reconstruction with autologous patch. Although extremely rare, saphenous leiomyosarcoma can present as deep vein thrombosis. Vascular tumors should be included in the differential diagnosis of atypical extremity swelling refractory to conventional deep vein thrombosis management.
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