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Related Experiment Video

Updated: May 4, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Changes in functional network centrality underlie cognitive dysfunction and physical disability in multiple

M M Schoonheim1, Jjg Geurts2, O T Wiebenga3

  • 1Department of Radiology and Nuclear Medicine, VU University Medical Center, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Center, The Netherlands m.schoonheim@vumc.nl.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|December 19, 2013
PubMed
Summary
This summary is machine-generated.

Brain network changes in multiple sclerosis (MS) are linked to cognitive and physical decline. Specifically, decreased connectivity in sensorimotor and ventral stream areas, alongside increased thalamic connectivity, correlates with MS-related dysfunction.

Keywords:
Multiple sclerosiscognitionconnectivityfunctional reorganizationhippocampusthalamus

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Graph Theory

Background:

  • Cognitive dysfunction significantly impacts quality of life in multiple sclerosis (MS).
  • The underlying mechanisms of cognitive impairment in MS remain poorly understood.

Purpose of the Study:

  • To investigate functional network integrity in MS patients.
  • To correlate functional network changes with cognitive dysfunction and physical disability.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) data from 128 MS patients and 50 controls.
  • Application of Eigenvector Centrality Mapping (ECM), a graph analysis technique, to assess brain region importance based on connectivity.
  • Analysis of relationships between ECM changes, physical disability (EDSS), and cognitive function.

Main Results:

  • MS patients showed increased ECM in the bilateral thalamus and posterior cingulate cortex (PCC).
  • Decreased ECM was observed in sensorimotor and ventral stream areas in MS patients.
  • Sensorimotor ECM decreases correlated with higher physical disability (EDSS), while ventral stream decreases correlated with poorer cognition.

Conclusions:

  • In MS, sensorimotor and ventral stream areas become less central in brain functional networks, correlating with clinical and cognitive dysfunction.
  • The thalamus exhibits increased connectivity with these affected areas in MS.
  • These findings contribute to understanding functional reorganization processes in MS and their impact on symptoms.