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When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
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The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
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Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
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Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.

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Related Experiment Video

Updated: May 4, 2026

Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology
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How to survive a nerve-wracking journey.

Andrea Yung1, Lisa V Goodrich

  • 1Andrea Yung is in the Department of Neurobiology, Harvard Medical School, Boston, United States andreayung@fas.harvard.edu.

Elife
|December 19, 2013
PubMed
Summary

Growing axons require Frizzled3 protein to navigate to their muscle targets. This protein is crucial for guiding nerve growth during development.

Area of Science:

  • Neuroscience
  • Developmental Biology

Background:

  • Axon guidance is essential for establishing functional neural circuits.
  • Proteins like Frizzled3 play multifaceted roles in cellular processes.

Purpose of the Study:

  • To investigate the role of Frizzled3 in guiding motor axons during development.

Main Methods:

  • Utilized genetic models and imaging techniques to observe axon growth.
  • Analyzed the function of Frizzled3 in neuronal development.

Main Results:

  • Demonstrated that Frizzled3 is necessary for the proper targeting of motor axons.
  • Identified Frizzled3 as a key guidance cue for growing axons.

Conclusions:

Keywords:
axon growthcell deathlimb innervationmuscle atrophyneural crestplanar cell polarity (PCP)

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  • Frizzled3 is a critical protein for ensuring motor axons reach their correct destinations.
  • This finding deepens our understanding of molecular mechanisms in neural development.