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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

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Histopathological implications of Aspergillus infection in lung

Naobumi Tochigi1, Yoichiro Okubo1, Tsunehiro Ando1

  • 1Department of Surgical Pathology, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo 143-8541, Japan.

Mediators of Inflammation
|December 19, 2013
PubMed

Insights

Invasive fungal infections, particularly invasive aspergillosis, present diagnostic and management challenges. This study highlights the importance of radiological and histopathological examinations for understanding Aspergillus pathogenesis.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pathology

Background:

  • Invasive fungal infections pose significant challenges in contemporary medicine due to difficult diagnosis and management.
  • Aspergillus species are recognized by cellular receptors and attacked by neutrophils, but radiological and macroscopic findings linking infection with neutropenia are not well-established.
  • Noninvasive and semi-invasive aspergillosis, including chronic necrotizing pulmonary aspergillosis, represent transitional forms requiring further investigation.

Purpose of the Study:

  • To emphasize the utility of radiological and histopathological examinations in understanding invasive aspergillosis.
  • To elucidate the complex interactions between causative microbes and host tissue responses in invasive aspergillosis.
  • To review noninvasive or semi-invasive aspergillosis, focusing on chronic necrotizing pulmonary aspergillosis.

Main Methods:

  • Discussion of classification, histopathological features, and pathophysiology of invasive fungal infections.
  • Review of radiological and macroscopic findings related to invasive aspergillosis.
  • Analysis of literature on noninvasive and semi-invasive aspergillosis.

Main Results:

  • Radiological and histopathological examinations provide crucial insights into the pathogenesis of invasive aspergillosis.
  • Understanding the interaction between Aspergillus and host tissues is complex.
  • Chronic necrotizing pulmonary aspergillosis is a transitional form, but findings are limited.

Conclusions:

  • Radiological and histopathological assessments are vital for diagnosing and managing invasive aspergillosis.
  • Further research is needed to confirm radiological and macroscopic findings in neutropenic patients with invasive aspergillosis.
  • More studies are required on chronic necrotizing pulmonary aspergillosis to clarify its role as a transitional form.

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