Plants and phytochemicals for Huntington's disease
Sunayna Choudhary1, Puneet Kumar2, Jai Malik1
1Department of Pharmacognosy, ISF College of Pharmacy, Moga, Punjab, India.
Pharmacognosy Reviews
|December 19, 2013
Summary
This review explores natural treatments for Huntington's disease (HD), a neurodegenerative disorder. It highlights plants and phytochemicals that may alleviate HD symptoms and offers insights into the disease's pathophysiology.
Area of Science:
- Neuroscience
- Genetics
- Pharmacology
Background:
- Huntington's disease (HD) is a progressive neurodegenerative disorder affecting striatal and cortical neurons.
- Pathogenesis involves genetic factors, oxidative stress, excitotoxicity, and mitochondrial dysfunction.
- Current treatments manage chorea but do not halt disease progression.
Purpose of the Study:
- To review the pathophysiology of Huntington's disease.
- To identify plants and phytochemicals with potential therapeutic effects on HD symptoms.
- To consolidate existing literature on natural interventions for HD.
Main Methods:
- Comprehensive literature search across major scientific databases (PubMed, Scopus, Google Scholar, etc.).
- Defined search strategy to identify relevant studies on HD pathophysiology and natural treatments.
- Review and synthesis of collected data on plants and phytochemicals.
Main Results:
- Multiple hypotheses explain HD pathogenesis, including genetic and metabolic factors.
- Several plants and phytochemicals demonstrate potential in alleviating HD-like symptoms in preclinical studies.
- Evidence suggests natural compounds may target pathways involved in neuronal dysfunction in HD.
Conclusions:
- Natural products offer a promising avenue for managing Huntington's disease symptoms.
- Further research into specific phytochemicals and their mechanisms is warranted.
- Integrative approaches combining conventional and natural therapies may benefit HD patients.
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