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Thymoquinone in the clinical treatment of cancer: Fact or fiction?

Majed M Abukhader1

  • 1Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman.

Pharmacognosy Reviews
|December 19, 2013
PubMed

Insights

Thymoquinone (TQ), derived from Nigella sativa seeds, shows significant anticancer potential. Further clinical studies are recommended to explore its efficacy in cancer treatment, particularly for breast cancer.

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Oncology

Background:

  • Thymoquinone (TQ) is a key bioactive compound from Nigella sativa seed oil.
  • Extensive in vitro and in vivo studies demonstrate TQ's anticancer properties.
  • Research has elucidated TQ's anti-proliferative mechanisms against various cancer models.

Purpose of the Study:

  • To review the anticancer potential of Thymoquinone (TQ).
  • To assess the viability of TQ in clinical cancer treatment.
  • To focus on TQ's application in breast cancer therapy.

Main Methods:

  • Literature review of existing in vitro and in vivo research on Thymoquinone.
  • Analysis of anti-proliferative activities and mechanisms of TQ.
  • Evaluation of TQ's transition from preclinical to clinical settings.

Main Results:

  • Thymoquinone exhibits significant anticancer effects in preclinical models.
  • A substantial body of evidence supports TQ's anti-proliferative activity.
  • Understanding of TQ's efficacy is enhanced by current research.

Conclusions:

  • Thymoquinone demonstrates considerable promise as an anticancer agent.
  • Clinical trials are warranted to validate TQ's therapeutic potential.
  • TQ may offer a novel treatment strategy, especially for breast cancer.
Keywords:
Breast cancerdrug deliverypharmacokineticsthymoquinone

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