Overdiagnosis of bipolar disorder: a critical analysis of the literature
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Updated: May 4, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Amna A Ghouse1, Marsal Sanches1, Giovana Zunta-Soares1
1UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, UT Houston Medical School, 1941 East Road, Houston, TX 77054, USA.
Abstract:
Bipolar disorder (BD) is considered one of the most disabling mental conditions, with high rates of morbidity, disability, and premature death from suicide. Although BD is often misdiagnosed as major depressive disorder, some attention has recently been drawn to the possibility that BD could be overdiagnosed in some settings. The present paper focuses on a critical analysis of the overdiagnosis issue among bipolar patients. It includes a review of the available literature findings, followed by some recommendations aiming at optimizing the diagnosis of BD and increasing its reliability.
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