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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Related Experiment Video

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Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
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Quantitative analysis of vascular calcification.

Jin Hyun Joh1, Dong Ik Kim2

  • 1Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul 134-727, Republic of Korea.

Experimental and Therapeutic Medicine
|December 19, 2013
PubMed
Summary
This summary is machine-generated.

Vascular calcification in atherosclerosis involves significant calcium and phosphate in arterial plaques. This study quantifies these minerals in abdominal aortic aneurysm and carotid artery stenosis plaques, providing reference values for future research.

Keywords:
calciummineral componentsphosphatevascular calcification

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Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Materials Science

Background:

  • Vascular calcification is a key characteristic of atherosclerosis.
  • The precise mineral composition of arterial plaques is not well understood.
  • Understanding plaque composition is crucial for studying vascular calcification.

Purpose of the Study:

  • To analyze the mineral composition and quantity within calcified arterial plaques.
  • To determine calcium, phosphate, iron, and zinc levels in plaques from abdominal aortic aneurysms (AAAs) and carotid artery stenoses.

Main Methods:

  • Calcified plaques were obtained from patients undergoing AAA repair and carotid endarterectomy (CEA).
  • Inductively coupled plasma atomic emission spectrometry (ICP-AES) was used for calcium and phosphate analysis.
  • Flame atomic absorption spectrometry (FAAS) was employed to measure iron and zinc concentrations.

Main Results:

  • Mean calcium concentrations were 9.83 wt.% in aortic plaques and 11.94 wt.% in carotid plaques.
  • Mean phosphate concentrations were 4.31 wt.% in aortic plaques and 6.08 wt.% in carotid plaques.
  • Iron levels in carotid plaques were below the detection limit; zinc concentrations varied.

Conclusions:

  • Calcium and phosphate are the primary mineral components of aortic and carotid plaques.
  • The quantified mineral concentrations serve as valuable reference data for vascular calcification studies.
  • Further research is needed to explore the relationship between mineral components and vascular calcification.