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Published on: March 1, 2011
Serum interleukin-18 levels are associated with physical activity in Japanese men
Kanae Oda1, Nobuyuki Miyatake1, Noriko Sakano1
1Department of Hygiene, Faculty of Medicine, Kagawa University, Kita, Kagawa, Japan.
Objective:
To investigate the link between serum interleukin-18 (IL-18) levels and physical activity in Japanese men.
Methods:
A total of 81 men (45.7±17.6 years old) was enrolled in this cross-sectional investigation study. We assessed anthropometric and body composition parameters. Serum IL-18 levels, physical activity by uniaxial accelerometers, peak oxygen uptake and metabolic risk parameters were also evaluated.
Results:
Serum IL-18 levels were 179.4±84.7 pg/mL. Physical activity evaluated by Σ[metabolic equivalents × h per week (METs⋅h/w)]was significantly and negatively correlated with serum IL-18 levels (r = -0.252, p = 0.0235). These associations remained even after adjusting for age, peak oxygen uptake and other confounding factors.
Conclusion:
Serum IL-18 levels were closely associated with physical activity independent of peak oxygen uptake in Japanese men.
