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Published on: May 21, 2013
Bone mesenchymal stem cells contributed to the neointimal formation after arterial injury
Mincai Li1, Suqin Li1, Liangzhu Yu2
1Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, HuBei University of Science and Technology, Xianning, China ; The Medical School, HuBei University of Science and Technology, Xianning, China.
Objectives:
Recent findings suggest that in response to repair-to-injury bone marrow mesenchymal stem cells (BMSCs) participate in the process of angiogenesis. It is unclear what role BMSCs play in the structure of the vessel wall. In present study, we aimed to determine whether BMSCs had the capacity of endothelial cells (ECs).
Methods:
BMSCs were separated and cultured. FACS and RT-PCR analysis confirmed the gene expression phenotype. The capacity of migration and adhesion and the ultrastructure of BMSCs were examined. The effect of BMSCs transplantation on the vascular repair was investigated in a murine carotid artery-injured model.
Results:
BMSCs could express some markers and form the tube-like structure. The migration and adhesion capacity of BMSCs increased significantly after stimulated. In addition, BMSCs had the intact cell junction. In vivo the local transfer of BMSCs differentiated into neo-endothelial cells in the injury model for carotid artery and contributed to the vascular remodeling.
Conclusion:
These results showed that BMSCs could contribute to neointimal formation for vascular lesion and might be associated with the differentiation into ECs, which indicated the important therapeutic implications for vascular diseases.
