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Association between ischemic stroke and iron-deficiency anemia: a population-based study
Yen-Liang Chang1, Shih-Han Hung2, Wells Ling3
1Department of Otolaryngology Head and Neck Surgery, Cathay General Hospital, Taipei, Taiwan ; School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
Plos One
|December 19, 2013
Summary
Iron-deficiency anemia (IDA) is linked to an increased risk of ischemic stroke. This nationwide study found a significant association, highlighting the importance of managing anemia to prevent stroke.
Area of Science:
- Neurology
- Hematology
- Public Health
Background:
- Limited understanding of non-sickle cell anemia's link to stroke.
- Investigating the association between iron-deficiency anemia (IDA) and stroke risk.
Purpose of the Study:
- To evaluate the association of iron-deficiency anemia (IDA) with stroke.
- Utilizing a nationwide health insurance database in Taiwan for comprehensive analysis.
Main Methods:
- Case-control study design.
- Included 51,093 stroke cases and 153,279 controls from Taiwan's Longitudinal Health Insurance Database 2000.
- Conditional logistic regression analysis to determine odds ratios (OR) for prior IDA diagnosis, adjusting for multiple confounding factors.
Main Results:
- A higher prevalence of prior IDA diagnosis was observed in stroke cases (2.48%) compared to controls (1.58%).
- Conditional logistic regression revealed an adjusted OR of 1.49 for prior IDA among stroke cases.
- A significant association was found between prior IDA and ischemic stroke (adjusted OR=1.45), but not with subarachnoid/intracerebral hemorrhage.
Conclusions:
- Prior iron-deficiency anemia is significantly associated with an increased risk of ischemic stroke.
- Findings suggest anemia management may be crucial for stroke prevention strategies.
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