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Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer

Ajay Rana1, Basabi Rana2, Rajakishore Mishra3

  • 1Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Maywood, IL, USA ; Hines Veterans Affairs Medical Center, Hines, IL, USA.

Genes & Cancer
|December 19, 2013
PubMed

Insights

Mixed lineage kinases (MLKs) are MAP3K family members involved in cell signaling. This review explores MLK biology and their emerging roles in cancer, including cell migration and apoptosis.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Mixed lineage kinases (MLKs) are a family of MAP3K enzymes.
  • MLKs activate mitogen-activated protein kinase (MAPK) pathways.
  • MLKs are implicated in neurodegenerative diseases and cancer.

Purpose of the Study:

  • To review the biology of MLK family members.
  • To discuss the current understanding of MLK functions in cancer.

Main Methods:

  • Literature review of MLK family members.
  • Analysis of MLK roles in cellular processes relevant to cancer.

Main Results:

  • At least 9 MLK members have been identified.
  • MLKs modulate cell migration, invasion, cell cycle, and apoptosis.
  • MLK functions in cancer are under active investigation.

Conclusions:

  • MLKs represent a significant area of research in oncology.
  • Further investigation into MLK functions may reveal novel cancer therapeutic targets.
Keywords:
JNKMAPKsMLKscancerphosphorylation

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