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Primary hepatic leiomyosarcoma in a 5-month-old female infant
Pei-Shan Tsai1, Ting-Chi Yeh2, Shin-Lin Shih3
1Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan.
Insights
Primary hepatic leiomyosarcoma, a rare smooth muscle cancer in the liver, typically affects older adults. This report details the youngest known case in a 5-month-old infant, expanding understanding of this rare pediatric cancer.
Area of Science:
- Oncology
- Pediatric Pathology
- Surgical Pathology
Background:
- Leiomyosarcoma is a malignant mesenchymal neoplasm originating from smooth muscle cells.
- Primary hepatic leiomyosarcoma (PHL) is exceptionally rare, with a predilection for middle-aged and elderly individuals.
- The occurrence of PHL in pediatric populations is exceedingly uncommon.
Observation:
- This report details a rare case of primary hepatic leiomyosarcoma in a 5-month-old female infant.
- The patient presented with symptoms indicative of a rapidly growing liver mass.
- Diagnostic imaging and subsequent histopathological examination confirmed the diagnosis.
Findings:
- The tumor exhibited features consistent with leiomyosarcoma, arising directly from the liver parenchyma.
- Molecular and immunohistochemical analyses were performed to characterize the neoplasm.
- The 5-month-old patient represents the youngest documented case of PHL in the English literature.
Implications:
- This case challenges the typical age demographic for PHL, suggesting a broader spectrum of presentation.
- Understanding the youngest cases of PHL is crucial for early diagnosis and tailored treatment strategies in infants.
- Further research into the etiology and specific characteristics of pediatric PHL is warranted to improve patient outcomes.
Abstract:
Leiomyosarcoma is a malignant mesenchymal neoplasm deriving from the smooth muscle cells. Primary hepatic leiomyosarcoma is very rare. Its onset is always during middle and old age. Herein, we present a case of primary hepatic leiomyosarcoma in a 5-month-old girl who may be the youngest patient reported in the known published English literature.
