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Updated: May 4, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Translational genomics in cancer research: converting profiles into personalized cancer medicine
Lalit Patel1, Brittany Parker1, Da Yang2
1Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; ; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Abstract:
Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.
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