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Streptococcus pneumoniae serotype distribution in children in the Russian Federation before the introduction of

Vladimir Tatochenko1, Sergey Sidorenko, Leila Namazova-Baranova

  • 1Scientific Center of Children Health, Russian Academy of Medical Science, 2/62, Lomonosovskiy avenue, Moscow, Russia.

Expert Review of Vaccines
|December 20, 2013
PubMed

Insights

Pneumococcal conjugate vaccines (PCVs) are recommended worldwide. This review of Russian studies highlights prevalent pneumococcal serotypes, informing potential disease reduction through PCV use in national immunization programs.

Area of Science:

  • * Epidemiology and Public Health
  • * Infectious Diseases
  • * Vaccinology

Background:

  • * The World Health Organization (WHO) recommends pneumococcal conjugate vaccines (PCVs) for global childhood immunization.
  • * Russia is considering PCVs for its National Immunization Programs, necessitating data on pneumococcal serotype distribution.
  • * Understanding serotype prevalence is crucial for estimating the potential impact of PCVs on disease burden.

Purpose of the Study:

  • * To review recent epidemiological studies on pneumococcal serotype distribution in Russia.
  • * To identify the most prevalent pneumococcal serotypes across various studies and isolate types.
  • * To assess the potential impact of PCV10 and PCV13 on disease reduction in Russia.

Main Methods:

  • * Systematic review of eight recent epidemiological studies on pneumococcal serotype distribution in Russia.
  • * Analysis of serotype prevalence data from diverse sources, including acute otitis media (AOM), community-acquired pneumonia (CAP), and nasopharyngeal isolates.
  • * Evaluation of antibiotic resistance patterns associated with specific serotypes.

Main Results:

  • * Serotypes 6B, 14, 19F, and 23F were consistently the most prevalent across reviewed studies.
  • * Serotype 3 was found to be relatively common, and serotype 19A showed significant prevalence in AOM, CAP, nasopharyngeal isolates, and antibiotic-resistant strains.
  • * PCV10 and PCV13 demonstrated varying serotype coverage, with differences up to 26%.

Conclusions:

  • * The current pneumococcal serotype distribution in Russia suggests that widespread PCV implementation could significantly decrease the burden of pneumococcal diseases.
  • * Serotype 19A is a notable target due to its prevalence in invasive and non-invasive infections and association with antibiotic resistance.
  • * Data-driven decisions on PCV selection (e.g., PCV10 vs. PCV13) are important for maximizing disease prevention in Russia.

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