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Ageing mechanisms and associated lipid changes.

Genovefa Kolovou, Niki Katsiki, Antonis Pavlidis

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Summary

Ageing involves somatopause, leading to physiological decline and macromolecule damage. This review explores ageing mechanisms and gender-specific lipid metabolism changes.

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Area of Science:

  • Gerontology and molecular biology.

Background:

  • Ageing is linked to the somatotropic axis slowdown (somatopause), causing physiological changes and macromolecule damage.
  • Current understanding of ageing mechanisms is incomplete, with theories including free radical damage, mitochondrial dysfunction, glycation, protein damage, and DNA damage.
  • Ageing is also modeled by genetic programming, telomere shortening, genomic instability, epigenetic alterations, and cellular senescence.

Purpose of the Study:

  • To review the multifaceted mechanisms of ageing.
  • To examine gender-specific alterations in lipid metabolism associated with the somatopause.

Main Methods:

  • Literature review of ageing theories and models.
  • Analysis of lipid metabolism changes in the context of ageing and gender.

Main Results:

  • The somatopause is associated with increased total cholesterol and triglyceride levels in both genders.
  • Multiple overlapping theories and models attempt to explain the complex process of ageing.

Conclusions:

  • Understanding ageing requires integrating various theories and models.
  • Lipid metabolism undergoes gender-specific modifications during the ageing process.