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Hyperthyroidism I: Introduction

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Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy

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Cardiac biomarkers in hyperthyroid cats.

J K Sangster¹, D L Panciera, J A Abbott

¹Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA.

Journal of Veterinary Internal Medicine

|December 20, 2013

Summary

This summary is machine-generated.

Cardiac biomarkers NT-proBNP and cTNI are elevated in hyperthyroid cats, similar to those with hypertrophic cardiomyopathy (HCM). These biomarkers do not differentiate between hyperthyroidism-associated and primary HCM in cats.

Keywords:

Cardiac troponin I Myocardial disease NT-proBNP

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Area of Science:

Veterinary Cardiology
Endocrinology
Internal Medicine

Background:

Hyperthyroidism significantly impacts feline cardiovascular health.
Cardiac biomarkers N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTNI) are established indicators of myocardial disease.
Their utility in hyperthyroid cats remains under-investigated.

Purpose of the Study:

To compare plasma NT-proBNP and cTNI concentrations in hyperthyroid cats, cats with subclinical hypertrophic cardiomyopathy (HCM), and healthy controls.
To evaluate changes in these biomarkers following treatment for hyperthyroidism.

Main Methods:

Prospective study involving hyperthyroid cats, cats with subclinical HCM, and healthy control cats.
Measurements included NT-proBNP, cTNI, echocardiography, and thyroid hormone levels.
Hyperthyroid cats were reassessed after radioiodine therapy.

Main Results:

Plasma NT-proBNP and cTNI concentrations were significantly higher in hyperthyroid cats and cats with HCM compared to healthy cats.
No significant difference in biomarker concentrations was observed between hyperthyroid cats and cats with HCM.
Following radioiodine treatment, hyperthyroid cats showed significant decreases in NT-proBNP, cTNI, and ventricular wall thickness.

Conclusions:

NT-proBNP and cTNI do not reliably distinguish cardiac changes due to hyperthyroidism from primary HCM in cats.
Thyroid status assessment is crucial before interpreting NT-proBNP and cTNI levels in older cats.
NT-proBNP may aid in monitoring cardiac response to hyperthyroid treatment.