Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

3.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.8K
Stem Cell Culture01:17

Stem Cell Culture

4.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
4.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.2K
Forced Transdifferentiation01:28

Forced Transdifferentiation

1.5K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension.

bioRxiv : the preprint server for biology·2026
Same author

A genome-wide deletion map in 125,730 individuals for novel rare disease gene and variant discovery.

medRxiv : the preprint server for health sciences·2026
Same author

Impaired SOX17 Expression Causes Endothelial Dysfunction and Pulmonary Arterial Hypertension by Insufficient Suppression of RUNX1.

bioRxiv : the preprint server for biology·2026
Same author

Hemodynamic and metabolomic responses to infusion of GLP-1 agonist exenatide in pulmonary arterial hypertension.

JCI insight·2026
Same author

Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension.

Science translational medicine·2026
Same author

Whole-protein screening and multi-modal profiling of antigen-specific CD4<sup>+</sup> T cells at single-cell resolution.

Nature communications·2026

Related Experiment Video

Updated: May 4, 2026

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
11:01

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids

Published on: September 25, 2016

7.0K

Regulating cell-based regenerative medicine: the challenges ahead.

Robin R Ali1, Anthony P Hollander, Paul Kemp

  • 1UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK.

Regenerative Medicine
|December 20, 2013
PubMed
Summary
This summary is machine-generated.

Regenerative medicine faces regulatory hurdles. This perspective outlines key challenges and proposes actionable steps for the UK and globally to advance this field.

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.3K
Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

4.1K

Related Experiment Videos

Last Updated: May 4, 2026

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
11:01

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids

Published on: September 25, 2016

7.0K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.3K
Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

4.1K

Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Healthcare Policy

Background:

  • The field of regenerative medicine is rapidly advancing, offering potential cures for various diseases.
  • Significant regulatory and policy challenges impede the translation of regenerative medicine therapies from laboratory to clinic.
  • Collaboration between academic, clinical, and industrial sectors is crucial for addressing these complex issues.

Purpose of the Study:

  • To identify and analyze the primary regulatory and related challenges in regenerative medicine.
  • To capture key insights from a UK-based working group comprising diverse stakeholders.
  • To propose actionable steps for overcoming these challenges in the UK and internationally.

Main Methods:

  • A perspective piece synthesizing discussions and ideas from a UK-based working group.
  • Inclusion of experts from academic, clinical, and industrial backgrounds.
  • Analysis of current regulatory landscapes and identification of potential solutions.

Main Results:

  • Key regulatory challenges hindering regenerative medicine development were identified.
  • Consensus was reached on critical areas requiring attention and strategic intervention.
  • A roadmap of recommended steps for regulatory enhancement was formulated.

Conclusions:

  • Addressing regulatory challenges is paramount for the successful advancement of regenerative medicine.
  • Coordinated efforts among stakeholders are essential to navigate the complex regulatory environment.
  • Implementation of proposed strategies can accelerate the delivery of regenerative therapies to patients worldwide.