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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Interlocus sexually antagonistic coevolution can create indirect selection for increased recombination.

Amy L Dapper1, Curtis M Lively

  • 1Department of Biology, Indiana University, 1001 E. 3rd Street, Bloomington, Indiana, 47405. adapper@indiana.edu.

Evolution; International Journal of Organic Evolution
|December 20, 2013
PubMed
Summary

Sexually antagonistic coevolution (SAC) favors recombination by creating fluctuating selection. This genetic mechanism can lead to very high recombination rates at equilibrium, offering a more permissive pathway than previously understood.

Keywords:
Epistasisheterogeneous selectionlinkage disequilibriumrecombination modifiersexual conflict

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Area of Science:

  • Evolutionary genetics
  • Sexual selection
  • Population genetics

Background:

  • Recombination's ubiquity challenges natural selection theory, as it disrupts favorable allele combinations.
  • Previous research linked host-parasite coevolution to fluctuating epistasis, favoring recombination.
  • Antagonistic coevolutionary dynamics are key to understanding genetic variation maintenance.

Purpose of the Study:

  • To investigate if interlocus sexually antagonistic coevolution (SAC) drives indirect selection for increased recombination rates.
  • To determine if SAC can lead to high equilibrium levels of recombination.
  • To compare the conditions favoring recombination under SAC versus host-parasite coevolution.

Main Methods:

  • Theoretical modeling of population genetics.
  • Analysis of selection dynamics under interlocus SAC.
  • Comparison of theoretical predictions with existing models of antagonistic coevolution.

Main Results:

  • Interlocus SAC creates significant heterogeneity in selection strength and direction, both within and between generations.
  • This heterogeneity maintains an excess of disadvantageous haplotypes, indirectly favoring recombination.
  • SAC can lead to very high levels of recombination at evolutionary equilibrium.

Conclusions:

  • Interlocus SAC provides a potent evolutionary pathway favoring recombination.
  • The conditions required for SAC to favor recombination are more permissive than those in host-parasite models.
  • SAC offers a novel explanation for the high prevalence of recombination in nature.