Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

35
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35
Dementia01:30

Dementia

687
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
687
Brain Imaging01:14

Brain Imaging

1.0K
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
1.0K
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

1.3K
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
1.3K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

853
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
853
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

541
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
541

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroradiology without benefit of computers: a memoir.

AJNR. American journal of neuroradiology·2009
Same author

Dinner at Keen's: the founding of the American Society of Neuroradiology.

AJNR. American journal of neuroradiology·2001
Same author

Jerry P. Petasnick, MD, President Radiological Society of North America, 2001.

Radiology·2001
Same author

Giovanni Di Chiro (1926-1997).

AJNR. American journal of neuroradiology·1998
Same author

Derek F. C. Harwood Nash, MB, ChB, DSc, FRCPC, FACR, FC RAD (SA).

AJNR. American journal of neuroradiology·1997
Same author

Precise placement of sphenoidal electrodes via fluoroscopic guidance.

AJNR. American journal of neuroradiology·1997
Same journal

Flow diversion for intracranial aneurysms in patients with sickle cell disease.

The neuroradiology journal·2026
Same journal

Perfusion imaging abnormalities in acute cerebral venous sinus thrombosis: A case series.

The neuroradiology journal·2026
Same journal

Enhancing neuroradiology education with systematic image and video sequences.

The neuroradiology journal·2026
Same journal

Inferior petroclival vein arteriovenous fistula mimicking cavernous sinus dural arteriovenous fistula: A case report.

The neuroradiology journal·2026
Same journal

Artificial intelligence in neuroradiology: From answers to judgment.

The neuroradiology journal·2026
Same journal

Vessel wall characteristics of the middle cerebral artery on high-resolution magnetic resonance imaging in patients with acute ischemic stroke.

The neuroradiology journal·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

1.1K

Imaging dementing illnesses.

M S Huckman1

  • 1Rush University Medical Center; Chicago, Illinois, USA - mhuckman@rush.edu.

The Neuroradiology Journal
|December 20, 2013
PubMed
Summary
This summary is machine-generated.

Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease (AD). Autopsies revealed significant AD pathology in over half of individuals with MCI, highlighting the importance of early clinical recognition.

More Related Videos

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.1K
Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

12.8K

Related Experiment Videos

Last Updated: May 4, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

1.1K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.1K
Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

12.8K

Area of Science:

  • Neurology
  • Gerontology
  • Pathology

Background:

  • Dementia is a decline in mental ability, affecting 1% over 40 and rising significantly with age.
  • Alzheimer disease (AD) and vascular dementia are leading causes, with mild cognitive impairment (MCI) as a potential precursor.
  • MCI involves memory problems but allows independent living; specific definitions include cognitive deficits relative to age and education.

Purpose of the Study:

  • To investigate the neuropathological basis of mild cognitive impairment (MCI).
  • To determine the prevalence of Alzheimer disease (AD) pathology and cerebral infarcts in individuals with MCI.
  • To assess the relationship between MCI and underlying brain pathologies.

Main Methods:

  • Autopsy analysis of 180 brains from a cohort of nuns and priests studied annually.
  • Categorization into groups: no impairment, mild cognitive impairment (MCI), and dementia.
  • Pathological assessment for Alzheimer disease (AD) markers and cerebral infarcts.

Main Results:

  • Over half (37) of individuals diagnosed with MCI showed significant Alzheimer disease (AD) pathology.
  • One-third of MCI cases had cerebral infarcts, and 5 had both AD pathology and infarcts.
  • Notably, 14 MCI cases had neither AD pathology nor infarcts, and one-third of the total cohort (age 85) showed no cognitive decline.

Conclusions:

  • Mild cognitive impairment (MCI) is frequently associated with underlying Alzheimer disease (AD) pathology.
  • Clinical recognition of MCI is crucial for potential therapeutic interventions, despite the current lack of effective treatments.
  • The study underscores the link between MCI and neurodegenerative changes, emphasizing its role as a precursor to dementia.