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Results from a randomized controlled trial comparing two low-calorie diet formulae
Martin Neovius1, Stephan Rössner1
1Obesity Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital (HS), SE-141 86 Stockholm, Sweden.
Obesity Research & Clinical Practice
|December 20, 2013
Summary
This study found that both Allévo® and Nutrilett® very low-calorie diets (VLCDs) are equally effective for short-term weight loss, BMI reduction, and body composition changes in obese men. Ketonaemia and compliance were similar between the two VLCDs.
Area of Science:
- Obesity research
- Nutritional science
- Metabolic studies
Background:
- Very low and low-calorie diets (VLCDs) are standard for initial obesity treatment.
- A new VLCD formula, Allévo®, has been introduced in Scandinavia.
- No prior studies compared Allévo® to the established Nutrilett® VLCD.
Purpose of the Study:
- To compare the short-term efficacy of Allévo® versus Nutrilett®.
- Assess effects on weight loss, BMI, ketonaemia, compliance, and body composition.
- Evaluate differences in protein and fiber content impact.
Main Methods:
- 36 obese males participated in an 8-week randomized trial.
- Compared two VLCDs (Allévo® and Nutrilett®) with differing compositions.
- Measured weight, BMI, waist circumference, and body fat percentage (DXA).
Main Results:
- No significant baseline differences in age, weight, blood pressure, or body fat percentage.
- Both VLCDs resulted in comparable reductions in BMI, weight, and waist circumference.
- Approximately 49% of weight loss was fat mass; ketonaemia was similar and did not correlate with weight loss.
Conclusions:
- Allévo® and Nutrilett® demonstrate equivalent efficacy for short-term weight and body composition changes.
- Both VLCDs are suitable alternatives for initial obesity management.
- Further research could explore long-term outcomes and broader population groups.
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