Asthma is associated with cardiovascular disease in a representative population sample
Sarah L Appleton1, Richard E Ruffin1, David H Wilson1
1The Health Observatory, Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville Road, South Australia 5011, Australia.
Obesity Research & Clinical Practice
|December 20, 2013
Summary
Asthma is linked to a higher risk of cardiovascular disease (CVD) and stroke, independent of traditional risk factors like obesity. However, asthma was not associated with an increased risk of diabetes in this population study.
Area of Science:
- Cardiology
- Pulmonology
- Endocrinology
Background:
- Inflammatory mediators common to asthma and cardiovascular disease (CVD) may increase risk for CVD and insulin resistance.
- This study investigated the association between asthma, CVD/stroke, and diabetes in a population-based sample, considering obesity's role.
Purpose of the Study:
- To determine if asthma prevalence is associated with increased CVD/stroke and diabetes.
- To examine if obesity modifies the relationship between asthma and these conditions.
Main Methods:
- Utilized data from the North West Adelaide Health Study (NWAHS) with 4060 participants (age ≥18).
- Assessed lung function (spirometry), anthropometry, blood pressure, glucose, HbA1c, and self-reported diagnoses of asthma, diabetes, and CVD/stroke.
- Asthma was defined by self-report or significant bronchodilator reversibility.
Main Results:
- Adjusted analyses showed asthma was not associated with diabetes (OR = 1.06, 95% CI: 0.45-2.49).
- Asthma remained significantly associated with CVD/stroke (OR = 1.82, 95% CI: 1.20-2.73) independently of BMI, smoking, and lung function.
- No interaction was found between asthma and BMI for CVD/stroke or diabetes. Asthma was not linked to CVD risk factors or metabolic syndrome.
Conclusions:
- In a population sample, asthma is associated with CVD/stroke after adjusting for traditional risk factors and lung function.
- Asthma may contribute to CVD events through mechanisms beyond established risk factors, warranting further research.
- Obesity did not significantly modify the association between asthma and CVD/stroke or diabetes.
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