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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
Cytotoxic T cell adoptive immunotherapy as a treatment for nasopharyngeal carcinoma
Viviana P Lutzky1, Pauline Crooks, Leanne Morrison
1Australian Centre for Vaccine Development and EBV Biology Laboratory, Department of Immunology, Queensland Institute of Medical Research, Brisbane, Australia.
Abstract:
Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). We assess the safety and tolerability of adoptive transfer of autologous cytotoxic T lymphocytes (CTLs) specific for the EBV latent membrane protein (LMP) in a patient with recurrent NPC. After infusion, the majority of pulmonary lesions were no longer evident, although the primary tumor did not regress.
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