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Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells
Published on: May 13, 2022
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Oxidative stress and neurodegenerative disorders
1Department of Geratology, First Hospital of Jilin University, Changchun, Jilin 130021, China. zjiang@panaceapharma.com.
International Journal of Molecular Sciences
|December 20, 2013
Summary
Reactive oxygen species (ROS) play dual roles in cells. Excessive ROS cause oxidative stress, damaging the nervous system and contributing to neurodegenerative diseases and chemotherapy side effects.
Area of Science:
- Neuroscience
- Biochemistry
- Pharmacology
Background:
- Living cells produce reactive oxygen species (ROS) during metabolism, which have physiological roles but can cause damage at high concentrations.
- The central nervous system (CNS) is highly susceptible to oxidative stress, leading to neurodegenerative diseases.
- Chemotherapy can induce neurotoxicity, with ROS implicated in these adverse effects.
Purpose of the Study:
- To review the generation, physiological roles, and balance of ROS.
- To explore the mechanisms of oxidative stress in neurodegenerative diseases and chemotherapy-induced neurotoxicity.
- To assess the therapeutic potential of antioxidants for neuroprotection.
Main Methods:
- Literature review of ROS metabolism, oxidative stress, neurodegeneration, and neurotoxicology.
- Analysis of the role of ROS in CNS and peripheral nervous system (PNS) disorders.
- Evaluation of antioxidant strategies for neuroprotection.
Main Results:
- ROS are essential but can be harmful when imbalanced, leading to oxidative stress.
- Oxidative stress is a key factor in neurodegenerative diseases and chemotherapy-induced neurotoxicity.
- Antioxidants show promise as neuroprotective agents.
Conclusions:
- Understanding ROS balance is crucial for nervous system health.
- Targeting ROS may offer new therapeutic avenues for neurodegenerative conditions and chemotherapy side effects.
- Further research is needed to optimize antioxidant therapies for neuroprotection.
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