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Updated: May 4, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Update on irritable bowel syndrome program of research
Margaret Heitkemper1, Monica Jarrett2, Sang-Eun Jun3
1Department of Biobehavioral Nursing & Health Systems, University of Washington, Seattle, USA. heit@uw.edu.
Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disorder. Understanding its complex pathophysiology and heterogeneity is key to effective nursing management and patient self-care strategies.
Area of Science:
- Gastroenterology
- Nursing Research
- Psychosomatic Medicine
Background:
- Irritable Bowel Syndrome (IBS) is a prevalent functional gastrointestinal disorder affecting adults globally.
- Characterized by abdominal pain and altered bowel habits, IBS impacts healthcare seeking behaviors, particularly in women aged 20-45.
- The disorder's pathophysiology involves a complex interplay of factors including gut-brain axis dysregulation, inflammation, and psychological influences.
Purpose of the Study:
- To provide an updated overview of a nursing research program on Irritable Bowel Syndrome (IBS).
- To explore the pathophysiology, diagnosis, and management of IBS.
- To emphasize the importance of the biopsychosocial model in understanding and treating IBS.
Main Methods:
- Literature review of English language papers published between 1999 and 2013.
- Inclusion of studies from the United States, Europe, and Asia (e.g., South Korea).
- Focus on IBS as a health problem, its etiologies, diagnostic and treatment approaches, and the biopsychosocial model.
Main Results:
- IBS is a chronic functional gastrointestinal disorder with diverse symptoms and potential contributing factors.
- Nurses play a crucial role in IBS symptom prevention and management, promoting patient self-management.
- Potential pathophysiological mechanisms include autonomic dysregulation, inflammation, dysbiosis, dietary factors, emotional regulation, visceral hypersensitivity, HPA axis dysfunction, and genetics.
Conclusions:
- Effective IBS management requires acknowledging the disorder's heterogeneity.
- Non-pharmacological interventions, including cognitive behavioral therapy, relaxation techniques, and dietary modifications, are vital.
- A comprehensive understanding of IBS pathophysiology informs personalized nursing care strategies.
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