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Updated: May 4, 2026

11:22
Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
Published on: August 17, 2016
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High mitochondrial accumulation of new gadolinium(III) agents within tumour cells
Daniel E Morrison1, Jade B Aitken, Martin D de Jonge
1School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. lou.rendina@sydney.edu.au.
Abstract:
The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10(10) Gd atoms per tumour cell.

