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Related Experiment Video

Updated: May 4, 2026

Transplantation of Bioengineered Lung Using Decellularized Mouse Lungs and Primary Human Endothelial Cells
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Transplantation of Bioengineered Lung Using Decellularized Mouse Lungs and Primary Human Endothelial Cells

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The development of the bioartificial lung.

Greg Lemon1, Mei Ling Lim2, Fatemeh Ajalloueian1

  • 1Department of Clinical Science, Intervention and Technology (CLINTEC), Advanced Center for Translational Regenerative Medicine (ACTREM), Karolinska Institutet, Stockholm, Sweden.

British Medical Bulletin
|December 20, 2013
PubMed
Summary

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Developing a bioartificial lung could revolutionize chronic lung disease treatment. Further research is needed to optimize cell differentiation, biomaterial interactions, and scaffold design for effective blood-gas exchange.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • Chronic lung disease incidence is rising globally due to risk factors and an aging population.
  • Bioartificial lungs offer a potential treatment advance by mimicking natural lung function.

Purpose of the Study:

  • To review the current state and future directions of bioartificial lung development.
  • To identify key challenges and areas for research in creating functional bioartificial lungs.

Main Methods:

  • Literature search of PubMed and ISI Web of Knowledge for bioartificial lung research.
  • Synthesis of findings regarding consensus, controversies, and future research needs.

Main Results:

  • Consensus exists on the benefit of bioartificial lungs for chronic lung failure.
Keywords:
artificial lunglung failurestem cells

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  • Ethical and safety concerns surround the use of human embryonic stem cells.
  • Interdisciplinary collaboration is crucial for success.

    • Conclusions:

    • Further research is needed in progenitor cell differentiation and cell-biomaterial interactions.
    • Advancements in biomaterial technology and mathematical modeling are essential for scaffold design and performance prediction.
    • Understanding lung regeneration mechanisms is key to harnessing the body's natural capacity.