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Phenoxybenzamine in prostatic hypertrophy. A double-blind study.

B G Ferrie, P J Paterson

    British Journal of Urology
    |January 1, 1987
    PubMed
    Summary
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    Phenoxybenzamine did not improve objective urinary flow in men with benign prostatic hypertrophy (BPH). While subjective hesitancy improved, side effects were more common, making it ineffective for BPH treatment.

    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • Benign prostatic hypertrophy (BPH) is a common condition affecting older men.
    • Pharmacological interventions aim to alleviate lower urinary tract symptoms (LUTS).

    Purpose of the Study:

    • To evaluate the efficacy and safety of phenoxybenzamine in treating BPH.
    • To assess objective and subjective improvements in urinary symptoms.

    Main Methods:

    • Double-blind, placebo-controlled study.
    • 45 patients awaiting prostatectomy participated.
    • Phenoxybenzamine 10 mg/day for 5 weeks compared to placebo.

    Main Results:

    • No significant differences in peak urine flow, voided volume, residual urine, or micturition frequency.

    Related Experiment Videos

  • Significant improvement in patient-reported hesitancy and flow symptoms with phenoxybenzamine.
  • Higher incidence of side effects in the phenoxybenzamine group (47.6%) versus placebo (22.2%).

    • Conclusions:

    • Phenoxybenzamine at 10 mg/day was ineffective for objective BPH symptom improvement.
    • Subjective symptom relief was noted but outweighed by increased side effects.
    • This dosage of phenoxybenzamine is not recommended for benign prostatic hypertrophy treatment.