Paternal factors in spontaneous first trimester miscarriage

Area of Science:

• Reproductive Medicine
• Obstetrics & Gynecology
• Epidemiology

Background:

• First-trimester miscarriage is a common pregnancy complication.
• Paternal factors are increasingly recognized as potential contributors to adverse pregnancy outcomes.
• Understanding these factors can aid in risk assessment and prevention strategies.

Purpose of the Study:

• To investigate the association between paternal age, tobacco use, and genital tract infections with the risk of spontaneous first-trimester miscarriage.
• To identify significant paternal risk factors for early pregnancy loss.

Main Methods:

• A case-control study involving 200 women with miscarriage and 400 controls.
• Data collected on paternal factors including age, tobacco use, and genital tract infections.
• Logistic regression analysis was employed to determine the significance of paternal factors.

Main Results:

• Paternal age over 35 years was significantly associated with an increased risk of first-trimester miscarriage (p=0.000).
• Genital tract infection in fathers showed a borderline significant association (p=0.043).
• Paternal age >35 years remained the sole significant predictor in the logistic regression model.

Conclusions:

• Paternal age exceeding 35 years is a significant risk factor for spontaneous first-trimester miscarriages.
• The findings underscore the importance of paternal age in early pregnancy outcomes.
• Further research may explore the mechanisms linking advanced paternal age to miscarriage.