Related Experiment Video

Updated: May 4, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

53.3K

Risk factors and mortality among newborns with persistent pulmonary hypertension

Athar Razzaq1, Ahmed Iqbal Quddusi2, Naila Nizami3

  • 1Dr. Athar Razzaq,MBBS, FCPS, Trainee Fellow in Neonatal Pediatrics, The Children Hospital &Institute of Child Health, Multan, Pakistan.

Pakistan Journal of Medical Sciences
|December 20, 2013
PubMed

Insights

Male gender, cesarean section, and birth asphyxia are key risk factors for persistent pulmonary hypertension of newborns (PPHN). These factors also increase mortality risk, particularly in preterm infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Perinatology

Background:

  • Persistent Pulmonary Hypertension of Newborns (PPHN) is a critical neonatal condition.
  • Identifying risk factors and mortality predictors is crucial for improving outcomes.

Purpose of the Study:

  • To investigate the risk factors associated with PPHN.
  • To analyze the impact of these risk factors on neonatal mortality.

Main Methods:

  • An observational study was conducted with 79 neonates diagnosed with PPHN.
  • Data collected included demographic, maternal, and perinatal factors.
  • Echocardiography confirmed hemodynamic shunting and Tricuspid regurgitation.

Main Results:

  • Male sex, cesarean delivery, and birth asphyxia were prominent risk factors for PPHN.
  • Cesarean delivery, birth asphyxia, and female sex were linked to higher mortality.
  • Respiratory Distress Syndrome (RDS), birth asphyxia, and male sex increased mortality risk in preterm infants.

Conclusions:

  • Male gender, cesarean delivery, Meconium Aspiration Syndrome (MAS), and RDS are significant risk factors for PPHN.
  • RDS, birth asphyxia, and male sex are associated with increased mortality in preterm neonates.
Abstract

Keywords:
Birth asphyxiaMeconium aspiration syndromePersistent pulmonary hypertension

More Related Videos

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure05:50

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

16.1K
Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

18.0K

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
906
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.5K
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
24
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.4K
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
1.5K
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
39