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Updated: May 4, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
22.1K
[Granulomatous lymphocytic interstitial lung disease in common variable immunodeficiency]
M Prella Bianchi1, I Letovanec2, F Spertini3
1Service de pneumologie, CHUV, Lausanne.
Revue Medicale Suisse
|December 21, 2013
Summary
Common variable immunodeficiency (CVID) causes infections and autoimmune issues. A lung condition, granulomatous lymphocytic interstitial lung disease (GLILD), is a major health concern for CVID patients.
Area of Science:
- Immunology
- Pulmonology
- Rheumatology
Context:
- Common variable immunodeficiency (CVID) is the most frequent primary immune deficiency.
- While immunoglobulin replacement reduces infections, CVID patients face inflammatory and autoimmune complications.
- Granulomatous lymphocytic interstitial lung disease (GLILD) is a significant pulmonary manifestation in CVID.
Purpose:
- To highlight the distinct nature of GLILD in CVID patients.
- To differentiate GLILD from infection-related lung disease and sarcoidosis.
- To underscore GLILD's contribution to CVID morbidity and mortality.
Summary:
- CVID, a primary immune deficiency, is linked to autoimmune and inflammatory conditions due to aberrant cellular immunity.
- Granulomatous lymphocytic interstitial lung disease (GLILD) is a recently identified lung disease affecting CVID patients.
- GLILD presents unique characteristics, differing from both infection-induced bronchiectasis and sarcoidosis, and is a critical cause of illness and death.
Impact:
- Increased awareness of GLILD as a distinct entity in CVID.
- Improved diagnostic differentiation between GLILD, bronchiectasis, and sarcoidosis.
- Potential for targeted therapies and better patient outcomes for CVID-associated lung disease.
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