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Updated: May 4, 2026
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
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Stress myocardial perfusion: imaging with multidetector CT
Alexia Rossi1, Daphne Merkus, Ernst Klotz
1From the Departments of Radiology (A.R., N.M., P.J.d.F., G.P.K.) and Experimental Cardiology (D.M.), Erasmus Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, the Netherlands; and Siemens Healthcare, Forchheim, Germany (E.K.).
Radiology
|December 21, 2013
Summary
Computed tomographic (CT) coronary angiography can detect coronary stenosis but struggles with functional significance. Stress myocardial perfusion CT imaging offers a promising solution for evaluating myocardial ischemia, improving diagnostic accuracy when combined with CT coronary angiography.
Area of Science:
- Cardiovascular imaging
- Radiology
- Medical diagnostics
Background:
- Computed tomographic (CT) coronary angiography is limited in assessing the functional significance of coronary stenosis.
- Anatomic and functional information is crucial for guiding patient care in coronary artery disease.
- Myocardial ischemia assessment often requires additional functional testing beyond CT coronary angiography.
Purpose of the Study:
- To review the physiology of coronary circulation and myocardial perfusion.
- To describe technical aspects, challenges, and modeling for CT perfusion imaging.
- To discuss recent advances, interpretation, and future research in CT perfusion.
Main Methods:
- Review of current literature on CT coronary angiography and myocardial perfusion.
- Discussion of CT perfusion imaging principles, including physiology and technical prerequisites.
- Analysis of advancements in CT scanner technology and perfusion protocols.
Main Results:
- Stress myocardial perfusion CT imaging can evaluate myocardial ischemia during vasodilator stress.
- Combining stress myocardial perfusion CT with CT coronary angiography improves diagnostic accuracy compared to CT coronary angiography alone.
- Optimization of CT perfusion acquisition protocols, including parameters, contrast injection, and radiation dose, is necessary.
Conclusions:
- Stress myocardial perfusion CT imaging shows potential for assessing myocardial ischemia and improving diagnostic accuracy.
- Further research is required to optimize CT perfusion protocols and establish clinical utility.
- CT perfusion imaging, combined with CT coronary angiography, may offer a comprehensive noninvasive assessment of coronary artery disease.
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