Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

164
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

279
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
279
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

236
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
236
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

352
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
352
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

137
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
137

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioinspired cross-aligned multilayered nanocellulose films through shear-induced orientation.

Journal of colloid and interface science·2026
Same author

<i>Carica Papaya</i> Linn. Leaf Extracts Induced the Proliferation of Mice's Peritoneal Macrophages and Bone Marrow Cells, Along with Cytokine Modulation in Cell Culture.

Journal of experimental pharmacology·2026
Same author

Phosphorylated Lignin-Cellulose Nanofibrils: Elucidating the Preparation Pathway and Structural Features.

Biomacromolecules·2025
Same author

Herbal medicines adulteration with erectile dysfunction pharmaceuticals in sub-Saharan Africa: call to strengthen regulatory measures.

Frontiers in medicine·2025
Same author

2-Oxo-2<i>H</i>-chromen-4-yl 4-ethyl-benzoate.

IUCrData·2025
Same author

Impacts of <i>SAYE PLUS</i>, an Antimalarial Phytomedicine With Potential Anti-COVID-19, on the Physical, Biological, and Genotoxicity Parameters of Rodents in Short-Term Toxicity Studies.

Journal of toxicology·2025

Related Experiment Video

Updated: May 4, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

9.2K

Progress in developing amphiphilic cyclodextrin-based nanodevices for drug delivery.

Josias B G Yaméogo, Annabelle Géze, Luc Choisnard

  • 1DPM, UMR CNRS 5063, ICMG FR 2607, Faculty of Pharmacy, University of Grenoble, France. denis.wouessidjewe@ujf-grenoble.fr.

Current Topics in Medicinal Chemistry
|December 21, 2013
PubMed
Summary

Amphiphilic cyclodextrins (CDs) self-assemble into stable nanoparticles for drug delivery, enhancing efficacy and reducing toxicity. This nanotechnology offers a promising approach for developing advanced pharmaceutical formulations and addressing global health challenges.

More Related Videos

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.2K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.4K

Related Experiment Videos

Last Updated: May 4, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

9.2K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.2K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.4K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Colloidal drug carriers improve drug bioavailability, efficacy, and safety.
  • Developing stable, self-assembling nanoscale materials is a key challenge.
  • Amphiphilic cyclodextrins (CDs) are investigated for their self-assembly into various colloidal systems.

Purpose of the Study:

  • To review the potential of structured nanoparticles from nonionic amphiphilic CDs for drug delivery and targeting.
  • To discuss the synthesis, characterization, and pharmaceutical applications of CD-based nanodevices.
  • To identify opportunities for using CD nanotechnology to address priority health problems.

Main Methods:

  • Review of literature on amphiphilic cyclodextrin synthesis and characterization.
  • Analysis of self-assembly into colloidal systems (micelles, nanoreservoirs, nanoparticles).
  • Evaluation of CD-based nanodevices for drug association, stability, and in vivo tolerance.

Main Results:

  • Amphiphilic CDs form stable nanoparticles with diverse supramolecular organizations (e.g., hexagonal, multilamellar).
  • These nanodevices exhibit good lipophilic drug association, stability, and in vivo tolerance.
  • Structured nanoparticles from nonionic amphiphilic CDs show significant potential in drug delivery.

Conclusions:

  • Nonionic amphiphilic cyclodextrin-based nanoparticles are effective drug delivery vehicles.
  • This nanotechnology offers advantages in stability, drug loading, and safety for pharmaceutical applications.
  • CD-based nanodevices present opportunities for tackling major global health issues.