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Endocrine autoimmunity in Turner syndrome
Armando Grossi, Antonino Crinò, Rosa Luciano
1Autoimmunity Laboratory, Immunology Area, Bambino Gesù Children's Hospital IRCCS, Piazza S, Onofrio, 4-00165 Rome, Italy. alessandra.fierabracci@opbg.net.
Italian Journal of Pediatrics
|December 21, 2013
Summary
Autoimmunity is common in Turner syndrome, particularly thyroid autoimmunity. Patients with X isochromosome have a higher risk, necessitating early monitoring for hypothyroidism.
Area of Science:
- Endocrinology
- Genetics
- Immunology
Background:
- Turner syndrome results from X chromosome abnormalities.
- Increased autoimmunity and autoantibodies are noted in Turner syndrome patients.
- This study analyzed autoimmunity incidence in 66 Italian Turner syndrome patients.
Purpose of the Study:
- To retrospectively analyze the incidence of autoimmunity in Italian Turner syndrome patients.
- To investigate the association between age, karyotype, and autoimmune disorders/autoantibodies.
- To identify specific karyotypes associated with a higher risk of autoimmunity.
Main Methods:
- Retrospective analysis of 66 Italian Turner syndrome patients.
- Examination of age, karyotype, and presence of autoimmune disorders/autoantibodies.
- Statistical analysis including Chi-squared and Fisher exact tests.
Main Results:
- 39.4% of Turner patients had thyroid autoimmune disorders.
- A statistically significant difference in thyroid autoimmunity incidence was observed across different karyotype groups (p=0.0173).
- Patients with X isochromosome showed a statistically higher frequency of thyroid autoimmunity (p=0.0315).
Conclusions:
- A high frequency of thyroid autoimmunity is confirmed in Italian Turner syndrome patients.
- X isochromosome karyotype is linked to an increased susceptibility to thyroid autoimmunity.
- Early autoantibody screening and thyroid hormone monitoring are crucial for timely hypothyroidism detection and treatment.
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