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Epidemiologic and genetic characteristics of mumps viruses isolated in China from 1995 to 2010

Aili Cui1, Zhen Zhu1, Meng Chen2

  • 1National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 102206, China.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|December 21, 2013
PubMed

Insights

Mumps remains endemic in China, particularly in Western regions, affecting children under 15. Genotype F has been the sole circulating mumps virus strain nationwide for 15 years.

Area of Science:

  • Epidemiology
  • Virology
  • Public Health

Background:

  • Mumps is an endemic disease in China.
  • Understanding the epidemiology and genetic diversity of mumps virus is crucial for public health interventions.
  • Previous studies have not provided a national-level overview of mumps virus characteristics in China.

Purpose of the Study:

  • To analyze the epidemiologic and genetic characteristics of mumps viruses in China between 1995 and 2010.
  • To identify regional and temporal patterns of mumps incidence.
  • To characterize the genetic makeup of circulating mumps virus strains.

Main Methods:

  • Retrospective analysis of mumps case data from 1995 to 2010.
  • Epidemiologic analysis including incidence rates, seasonality, and age distribution.
  • Genetic analysis of mumps virus strains, focusing on the small hydrophobic (SH) gene.
  • Phylogenetic analysis to determine genotype and transmission chains.

Main Results:

  • Mumps incidence was high and endemic across China, with higher rates in Western China.
  • The primary incidence peak occurred from April to July, with a secondary smaller peak in November-December.
  • Mumps predominantly affected individuals under 15 years of age.
  • Genotype F was the only detected genotype circulating throughout China during the study period.
  • Multiple, geographically widespread transmission chains of genotype F were identified.

Conclusions:

  • Mumps virus genotype F has been consistently dominant in China for at least 15 years.
  • The findings provide a comprehensive national-level understanding of mumps epidemiology and virology in China.
  • This data can inform targeted public health strategies for mumps prevention and control.
Keywords:
EpidemiologyGenetic characteristicsMumps virus

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