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Updated: May 4, 2026

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
Published on: December 10, 2020
Comparison of four types of membrane bioreactor systems in terms of shear stress over the membrane surface using
1University of Los Andes, Department of Chemical Engineering, Product and Process Design Group (GDPP), Cra 1 No. 18A-12, Bogota, Colombia
Abstract:
Membrane bioreactors (MBRs) have been used successfully in biological wastewater treatment to solve the perennial problem of effective solids-liquid separation. A common problem with MBR systems is clogging of the modules and fouling of the membrane, resulting in frequent cleaning and replacement, which makes the system less appealing for full-scale applications. It has been widely demonstrated that the filtration performances in MBRs can be greatly improved with a two-phase flow (sludge-air) or higher liquid cross-flow velocities. However, the optimization process of these systems is complex and requires knowledge of the membrane fouling, hydrodynamics and biokinetics. Modern tools such as computational fluid dynamics (CFD) can be used to diagnose and understand the two-phase flow in an MBR. Four cases of different MBR configurations are presented in this work, using CFD as a tool to develop and optimize these systems.
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