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[Programmed cell death comes in many flavors]

Lauriane Cabon1, Ana-Carolina Martinez-Torres1, Santos A Susin1

  • 1Inserm U872, équipe 19 « mort cellulaire programmée et physiopathologie des cellules tumorales », Centre de recherche des Cordeliers, Université Pierre et Marie Curie, Université Paris-Descartes, Sorbonne-Universités, UMRS 872, 15, rue de l'École de Médecine, 75006 Paris, France.

Medecine Sciences : M/S
|December 21, 2013
PubMed

Insights

Programmed cell death encompasses more than apoptosis, with various alternative pathways like necroptosis and pyroptosis playing crucial roles in eliminating unwanted cells. Understanding these diverse cell death mechanisms is vital for biological research.

Area of Science:

  • Cell Biology
  • Molecular Biology

Context:

  • Apoptosis is widely recognized as programmed cell death.
  • Alternative programmed cell death pathways are increasingly described.

Purpose:

  • To review diverse programmed cell death subtypes beyond apoptosis.
  • To highlight the characteristics and significance of various cell death pathways.

Summary:

  • This review details multiple programmed cell death pathways, including anoikis, necroptosis, entosis, netosis, pyroptosis, and ferroptosis.
  • These pathways differ in characteristics and are utilized based on cell type, tissue origin, and developmental stage.
  • Programmed cell death is essential for removing damaged or dangerous cells in organisms.

Impact:

  • Expands understanding of cellular mechanisms of death.
  • Provides insights into the diverse biological roles of programmed cell death.
  • Contributes to the broader knowledge of cell biology and organismal health.

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