Related Experiment Video
Updated: May 4, 2026

Estimation of Telomeric Repeat-containing RNA from DNA/RNA Hybrid Complexes
Published on: December 5, 2025
[RTEL1 (regulator of telomere elongation helicase 1), a DNA helicase essential for genome stability]
Tangui Le Guen1, Laurent Jullien1, Mike Schertzer2
1Dynamique du génome et système immunitaire, Institut Imagine, 149, rue de Sèvres, 75015 Paris, France - Inserm U768, université Paris Descartes, Sorbonne Paris Cité, Institut Imagine, 149, rue de Sèvres, 75015 Paris, France.
Abstract:
RTEL1 (regulator of telomere length helicase 1) is a DNA helicase that has been identified more than 10 years ago. Many works since, mainly in the nematode Caenorhabditis elegans and the mouse, have highlighted its role in chromosomal stability, maintenance of telomere length, and DNA repair. Recently, four laboratories have characterized RTEL1 mutations in patients with dyskeratosis congenita (DC) and Hoyeraal-Hreidarsson (HH) syndrome, a rare and severe variant of DC. We here summarize the current knowledge on RTEL1 and discuss the possible other functions that RTEL1 could play.
More Related Videos
11:21Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
Published on: August 30, 2024
09:13Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
Published on: January 17, 2019
Related Concept Videos
Telomeres and Telomerase
Telomeres and Telomerase
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes
DNA Helicases
Replicative Cell Senescence