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Plasma fibronectin levels in patients with glomerular proteinuria
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1986
Summary
Plasma fibronectin levels are elevated in patients with glomerular proteinuria, correlating with cholesterol levels. This finding suggests increased fibronectin may contribute to thrombotic risk in nephrotic syndrome.
Area of Science:
- Nephrology
- Clinical Chemistry
- Immunology
Background:
- Glomerular proteinuria is a hallmark of kidney disease.
- Nephrotic syndrome (NS) presents with proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
- Thrombotic complications are a significant concern in NS.
Purpose of the Study:
- To investigate plasma fibronectin concentrations in patients with glomerular proteinuria.
- To correlate plasma fibronectin levels with clinical and biochemical parameters.
- To assess the potential role of fibronectin in thrombotic risk in NS.
Main Methods:
- Rocket immunoelectrophoresis was used to measure plasma fibronectin.
- 20 patients with glomerular proteinuria were studied.
- Correlations were performed with urinary protein loss, serum albumin, cholesterol, alpha 1 antitrypsin, and alpha 2 macroglobulin.
Main Results:
- Plasma fibronectin was significantly elevated in patients compared to controls (1.91 U/ml vs 1.01 U/ml, p < 0.001).
- Plasma fibronectin showed a significant positive correlation with cholesterolemia (r = 0.662, p < 0.001).
Conclusions:
- Elevated plasma fibronectin is observed in glomerular proteinuria.
- Increased plasma fibronectin may serve as an additional risk factor for thrombotic events in nephrotic syndrome.