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SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements

Giulia Antoniali1, Lisa Lirussi, Chiara D'Ambrosio

  • 1Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy Proteomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, 80147 Naples, Italy Department of Biomedical and Pharmaceutical Sciences, University of Salerno, 84084 Fisciano (Salerno), Italy Department of Pharmacy, University of Naples "Federico II," 80134 Naples, Italy Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.

Molecular Biology of the Cell
|December 21, 2013
PubMed
Summary

Apurinic/apyrimidinic endonuclease 1 (APE1) binds to negative calcium responsive elements (nCaRE) in gene promoters. This protein complex regulates gene expression, particularly the SIRT1 gene, during oxidative stress responses.

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