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Updated: May 4, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Physiologically relevant organs on chips.

Kyungsuk Yum¹, Soon Gweon Hong, Kevin E Healy

¹Department of Bioengineering, University of California, Berkeley, CA, USA; Department of Materials Science and Engineering, University of Texas, Arlington, TX, USA.

Biotechnology Journal

|December 21, 2013

Summary

This summary is machine-generated.

Microengineered organs-on-chips recreate human organ physiology for drug development and disease modeling. This technology offers a promising alternative to traditional cell cultures and animal models.

Keywords:

Microengineering Microfluidics Organs-on-chips Physiologically relevant microenvironment Tissue engineering

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Last Updated: May 4, 2026

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Area of Science:

Biomedical Engineering
Tissue Engineering
Microfluidics

Background:

Microengineering and tissue engineering advances enable sophisticated physiological models.
Microengineered physiological systems, or organs-on-chips, mimic human tissues and organs.

Purpose of the Study:

To review the development of organs-on-chips technology.
To highlight their potential in experimental medicine and drug development.

Main Methods:

Microengineering approaches to create organ-specific microenvironments.
Reconstitution of tissue structures, interactions, and dynamic stimuli.
Development of single and multiple organ-on-chip systems.

Main Results:

Successful creation of microengineered models that replicate organ-level functions.
Demonstration of simulating multiple organ interactions and human responses to drugs.
Validation of organs-on-chips as functional physiological systems.

Conclusions:

Organs-on-chips technology represents a significant advancement in experimental medicine.
This technology has the potential to replace traditional 2D/3D cell cultures and animal models.
It offers improved human disease modeling, drug development, and toxicology assessment.