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Related Experiment Video

Updated: May 4, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

The pathogenesis of keratoconus.

A E Davidson¹, S Hayes², A J Hardcastle¹

¹Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK.

Eye (London, England)

|December 21, 2013

Summary

Keratoconus, a common cause of vision loss, is a degenerative eye condition. Its exact causes are unknown, but research suggests both genetic and environmental factors contribute to its development.

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Area of Science:

Ophthalmology
Genetics
Environmental Health

Background:

Keratoconus (KC) is a prevalent degenerative corneal disease causing significant visual impairment.
It is the leading indication for corneal transplantation in developed nations.
The etiology of KC remains largely unknown, with multifactorial influences suspected.

Purpose of the Study:

To review current knowledge on the causes and risk factors of keratoconus.
To consolidate understanding of the multifactorial nature of KC.
To identify gaps in current research for future therapeutic development.

Main Methods:

Literature review of existing studies on keratoconus etiology.
Synthesis of data regarding genetic predispositions.
Analysis of environmental factors implicated in KC development.

Main Results:

Current understanding points to a complex interplay of genetic and environmental factors in KC pathogenesis.
Specific genetic loci and environmental exposures are being investigated as potential contributors.
Significant gaps remain in fully elucidating the disease mechanisms.

Conclusions:

Further research is needed to fully understand the etiology of keratoconus.
Identifying specific risk factors may pave the way for targeted therapies.
A comprehensive understanding is crucial for developing advanced treatments for KC.